UCSF School of Medicine - Physical Therapy and Rehabilitation

Kimberly S. Topp, PT, PhD
Professor and Chair

Department of Physical Therapy and Rehabilitation Science

Sexton Sutherland Endowed Chair in Human Anatomy Department of Anatomy

toppk@ptrehab.ucsf.edu
415-476-9449

Dr. Topp's research interests are in the pathobiology and treatment of peripheral neuropathies. In her studies of painful neuropathy induced by cancer chemotherapeutic drugs in animal models, she has demonstrated quantitative changes in sensory neuron microtubules and neurofilaments, as well as degenerative changes in primary sensory neurons following vincristine chemotherapy. With DPTSc graduate, Meredith Wampler, she has quantified alterations in somatosensory and vestibular functions in patients with breast cancer treated with the chemotherapeutic drug, taxol.
One of Dr. Topp's research areas is in traumatic nerve injury and response of nerve to physical stress. She and DPTSc graduate, Benjamin Boyd, recently published a review and interpretation of the literature describing the macroscopic and microscopic anatomy of peripheral nerve, and changes in nerve structure and biomechanics that occur in response to physical stresses placed on nerve during everyday activities. Dr. Topp and Ben have measured significant increases in nerve strain in the first three weeks after mild traumatic injury to the sciatic nerve in a rat model. They have correlated the alterations in biomechanical properties after injury with functional changes in animal gait using a novel pressure mapping system. Subsequently, they carried this work to the clinical population, investigating the subjective and objective responses to the neurodynamic clinic test, the straight leg raise in control subjects and subjects with diabetes mellitus.
Dr. Topp is discipline leader for the anatomy curriculum for the Essential Core of the School of Medicine and a member of the UCSF Academy of Medical Educators. She teaches in several academic blocks, including Prologue, Organs, Metabolism and Nutrition, Infection, Immunity and Inflammation, Mechanisms Methods and Malignancies, Life Cycle and Epilogue. She has shared curricular innovations for teaching anatomy through academic publications.
Dr. Topp is Chair of the Department of Physical Therapy and Rehabilitation Science, and teaches Neuromuscular Anatomy, Review of Functional Anatomy and Nerve Biology and Biomechanics within the UCSF/SFSU Graduate Program in Physical Therapy.

Chemotherapy-induced neuropathy:
Topp, K.S., Tanner, K.D., and J.D. Levine. Damage to the cytoskeleton of large diameter sensory neurons and myelinated axons in vincristine-induced painful peripheral neuropathy in the rat. J. Comp. Neurol. 424:563-576, 2000.
Wampler, M.A., Miaskowski, C., Hamel, K., Byl, N., Rugo, H., and Topp, K.S. The modified Total Neuropathy Score: a clinically feasible and valid measure of taxane-induced peripheral neuropathy in women with breast cancer. J. Supportive Oncol. 4:397-403,2006.
Smoot, B., Wampler, M. and Topp, K. Breast cancer treatments and complications: Implications for rehabilitation. Rehabilitation Oncology (2009, in press).

Nerve structure and biomechanics:
Boyd, B., Puttlitz, C., Gan, J., Topp, K.S. Strain and excursion in the rat sciatic nerve during a modified straight leg raise are altered after traumatic nerve injury. J Orthop Res. 23:764-770, 2005.
Topp, K.S., and Boyd, B. Structure and biomechanics of peripheral nerve: Nerve responses to physical stresses and implications for physical therapist practice. Phys. Ther. 86:92-109, 2006.
Boyd, B.B., Wanek, L., Gray, A.T., Topp, K.S. Mechanosensitivity of the lower extremity nervous system during straight leg raise neurodynamic testing in healthy individuals. J. Orthop. Sports Phys. Ther. (2009, in press).

Anatomy teaching:
Topp, K.S. Prosection versus dissection: the debate continues. The Anat Rec, 281B:12-14, 2004.
Chou, CL, Topp, KS, O'Sullivan, P. Multidisciplinary teaching of the musculoskeletal physical examination. Med. Educ. 40:481-482, 2006.
Zaid, H., Ward, D., Samman, A., Topp, K., Tendick, F., Maa, J. 2008. Integrating surgical skills into the anatomy laboratory. J. Surgical Res. (in press on line PMID: 19159909), 2008.

Location
University of California, San Francisco
LR208 Radiobiology Bldg (Parnassus)
San Francisco, CA 94143-0736