Dr. Rosi investigates how neuroinflammation alters the neurobiological bases of leaning and memory. She is studying the biology of microglial and astroglial activation in vivo to gain further insight into its role in brain pathology. Her long-term research goal is to use a multidisciplinary approach to understand how neuroinflammation alters the ensemble dynamics in the network of brain structures that undergo plasticity. Her main question is to understand the communication between neurons and altered glial and how glial presence affects neuronal function; how activated glia could modulate neuronal activity, and how these two interconnected systems interact with each other to produce the cognitive dysfunction characteristic of many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, HIV dementia and autism.

Her focus is to understand the molecular mechanisms responsible for inflammation-associated dysfunction and damage in the CNS with the final goal of identifying potential therapeutic targets for the treatment of brain injury and neuroinflammatory-related neurodegenerative disease.

Location
University of California, San Francisco
1001 Potrero Ave, Room 101 (SFGH)
San Francisco, CA 94143-0899